In Mark 14:25, Jesus told his disciples that he would not drink again from the fruit of the vine until the day when he drinks it new in the kingdom of God. Presumably, Jesus refused to drink from this wine because he does not want to dull the pain. Jesus chooses to scorn the pain and drink instead the whole cup of suffering that God has given to him (Mark 10:38; Mark 14:36).1
23 And they offered him wine mixed with myrrh, but he did not take it.