The name Enosh characterizes man as a vulnerable being. However, whoever calls on God’s name lives an immortal life (see e.g., Acts 2:21). The calling upon God’s name
is reported here for the first time. It turns out to be an activity that is characteristic of God’s children throughout (biblical) history. It primarily refers to prayer. In prayer you mention God’s name to honour and praise him, to ask him to complete his work, to present your questions and needs to him, and to express confidence in his answer (compare the prayer that Christ taught us, with the salutation Our Father who are in heaven
). In practice, this invocation is surrounded by more and more (liturgical) acts: singing, confessing, teaching from God’s revelations, helping the poor and weak, receiving God’s blessing, so that calling upon God’s name
becomes the expression for the coming together of God’s children in moments of dedicated service to God: worship services. You could therefore say that what we call church or worship today began in Genesis 4:26. Through this, mankind achieves its goal (compare what the living entities in heaven are doing according to Revelation 4:1–11 and Revelation 5:1–14). God does not reject a prayer. Calling on God’s name saves, because God answers.
With this encouragement, this chapter of God’s first public lesson on sin (Genesis 4) closes—in the fight against it. The weapons of the equipped fighter against sin results in an invocation of God’s name (Ephesians 6:18).
26 To Seth also a son was born, and he called his name Enosh. At that time people began to call upon the name of the LORD.