God’s people live in this world where temptations abound to seek happiness in created things instead of in the Creator. The Lord’s instruction to his people of all times and places is to come out of her,
that is, to distance oneself from this earth-centred mindset. Obedience to this instruction does not mean that God’s people should retreat from society or form a ghetto; it means instead that we make a conscious decision (and remake it daily as well as act on it repeatedly) to seek and find our sense of well-being and contentment in the Lord God alone. So Paul could be content in the solitude and poverty of prison (Philippians 4:11–12, Philippians 4:19).
4 Then I heard another voice from heaven saying, “Come out of her, my people, lest you take part in her sins, lest you share in her plagues;