Matthew 24:15–16 (ESV)

15 “So when you see the abomination of desolation spoken of by the prophet Daniel, standing in the holy place ( let the reader understand),

However, [Antiochus Epiphanes] was not to be the last abomination that makes desolate. Our Lord Jesus Christ, in Matthew 24:15, said that there was another historical type of the Antichrist who was going to come shortly after Christ's death. And that historical type was someone who would also set up another abomination of desolation.

When ye therefore shall see the abomination of desolation, spoken of by Daniel the prophet, stand in the holy place, (whoso readeth, let him understand:) then let them which be in Judaea flee into the mountains. Matthew 24:15–16, KJV

The Lord Christ is referring there to the Roman Emperor Titus, who destroyed the temple in Jerusalem in 70 A.D. And when he destroyed that temple, he set up the Roman standard right on the temple mount and called all there to gather around and to worship the Roman standard in the temple place where Jehovah was to be worshipped; an abomination that makes desolate the worship of God.1

Cory Griess