We see here that when Antiochus has made peace with Egypt, he goes on to expand his power in Europe. He especially conquers countries situated along the coast: regions where there is a thriving trade. Then follows a decisive battle with the Romans in 190 BC. The commander spoken of in this verse is Lucius Cornelius Scorpio. Before the battle, Antiochus had proudly boasted that he was invincible. The Lord uses the Roman commander to bring down the haughty Antiochus. Those who exalt themselves will be humbled.
Between 50,000 to 80,000 Syrian soldiers die in this battle. A very high tribute is imposed on Antiochus that he is forced to pay to the Romans every year. As a powerless man Antiochus needs to return to his own country. His power and greatness are broken.
18 Afterward he shall turn his face to the coastlands and shall capture many of them, but a commander shall put an end to his insolence. Indeed, he shall turn his insolence back upon him.